Mercedes-Benz has for years pursued the vision of accident-free driving: the integral safety concept developed for this covers every phase of automotive safety – from handling safety through to safety in hazardous situations and protection in the event of an accident, not to mention minimising the consequences of an accident. Safety is also integrated as standard in the Citaro hybrid. The body already protects the passengers in the event of a side impact. In the event of a collision with a vehicle in front, the reinforced front section minimises the consequences of an accident and protects the driver.

Increased safety thanks to the optimum view afforded to the driver, for example, is ensured by the optional and especially durable LED main-beam headlamps. They offer a particularly good illumination of the road surface thanks to precisely adjustable light cones. The light colour is comparable to daylight and consequently causes less strain on the driver's eyes, resulting in less fatigue.